Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Orthodenticlehomeobox 1 (OTX1) overexpression had previously been associated with the progression of several tumors.
|
27478331 |
2016 |
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
We selected nasal and sinonasal adenocarcinomas to investigate the expression of OTX1 and OTX2 genes through immunohistochemical and real-time PCR analyses.Both OTX1 and OTX2 were absent in all the samples of sinonasal Intestinal-Type Adenocarcinomas (ITACs).
|
30882801 |
2019 |
Medulloblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Northern blot (n = 10) and reverse transcriptase-polymerase chain reaction (n = 45) analyses demonstrated that virtually all medulloblastomas expressed OTX1, OTX2, or both.
|
16462208 |
2006 |
Neoplasm Metastasis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas.
|
28348423 |
2017 |
Olfactory Neuroblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
OTX1 mRNA was identified only in Non-Intestinal Type Adenocarcinomas (NITACs) while OTX2 mRNA was expressed only in Olfactory Neuroblastomas (ONs).
|
30882801 |
2019 |
Tumor Cell Invasion
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Functional analyses reveal that overexpression of OTX1 results in accumulation of CRC cell proliferation and invasion in vitro and tumor growth in vivo, whereas ablation of OTX1 expression significantly inhibits the proliferative and invasive capability of CRC cells in vitro.
|
24388989 |
2014 |
Malignant neoplasm of breast
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation.
|
21478910 |
2011 |
Proliferative vitreoretinopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
PVR samples showed little or no expression of Otx1 and variable expression of VEGF-A, Otx2, Otx3, p53, and p63 genes.
|
24227910 |
2013 |
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OTX1 has been described as a critical molecule for axon refinement in the developing cerebral cortex of mice, and its activity in breast cancer suggests a synergistic function with p53 in CSC differentiation.
|
21478910 |
2011 |
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of OTX1 was positively correlated with nodal metastasis status (P = 0.009) and TNM staging (P = 0.001) in HCC tissues.
|
27478331 |
2016 |
Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
We have demonstrated that the differential gene expression for both OTX1 and OTX2 genes might be a useful molecular marker to distinguish the different types of sinonasal tumors.
|
30882801 |
2019 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
As a strategy to define the embryonic origin and neurochemical phenotype of cells in this disease, we probed specimens (n = 10) resected during epilepsy surgery with a panel of 13 antibodies recognizing proteins associated with (i) specific progenitor cell types including brain lipid binding protein (BLBP), collapsin response mediator protein 4 (CRMP4), Dlx1, Dlx2, GFAPdelta, MASH1, Otx1, Pax6, vimentin and phosphorylated vimentin and (ii) excitatory or inhibitory neurochemical phenotypes such as the vesicular glutamate transporters-1 and 2 (VGLUT-1, VGLUT-2), or the vesicular GABA transporter (VGAT).
|
17711980 |
2007 |
Epilepsy
|
0.020 |
Biomarker
|
disease |
BEFREE |
Otx1 null mice exhibit spontaneous epileptic seizures and multiple abnormalities affecting primarily the dorsal telencephalic cortex and components of the acoustic and visual sense organs.
|
10068635 |
1999 |
Medulloblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
OTX1 and OTX2 Genes in Medulloblastoma.
|
30797919 |
2019 |
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, our data indicated that OTX1 functions as a key regulator in tumor growth and metastasis of GC cells.
|
30066897 |
2018 |
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Dowregulation of OTX1 attenuates gastric cancer cell proliferation, migration and invasion.
|
30066897 |
2018 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lncRNA FEZF1-AS1 promotes the progression of colorectal cancer through regulating OTX1 and targeting miR-30a-5p.
|
31270006 |
2020 |
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Together, our results indicate that OTX1 is involved in human colon carcinogenesis and may serve as a potential therapeutic target for human colorectal cancer.
|
24388989 |
2014 |
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study.
|
28049011 |
2017 |